Citalopram is a substrate of which cytochrome enzyme?

Citalopram is metabolized in the liver primarily by the cytochrome P450 enzyme CYP2C19. This enzyme plays a crucial role in the biotransformation of citalopram into its active metabolites, affecting its pharmacokinetics and overall therapeutic efficacy. Understanding the metabolism of citalopram through CYP2C19 is essential for predicting potential drug interactions, especially in individuals who may be taking other medications that are also metabolized by this enzyme or who may have genetic variations affecting CYP2C19 function. This information is particularly useful for healthcare providers when considering dosage adjustments or monitoring side effects in patients on citalopram therapy.

The other cytochrome enzymes mentioned, such as CYP3A4, CYP1A2, and CYP2D6, do not primarily metabolize citalopram, making them less relevant in this context.