Do Sulindac or Aspirin impact Lithium concentration?

Sulindac and Aspirin do not significantly impact lithium concentration. Lithium is primarily eliminated through the kidneys, and its levels can be affected by factors such as hydration status and renal function. However, both Sulindac and Aspirin are non-steroidal anti-inflammatory drugs (NSAIDs) that typically do not have a significant interaction with lithium in terms of altering its serum levels.

While other medications may influence lithium concentration, such as those affecting renal clearance, NSAIDs like Sulindac and Aspirin are not known to cause meaningful changes in lithium levels under typical circumstances. This distinction is important for managing patients who are on lithium therapy, as maintaining consistent lithium levels is crucial for effective treatment.