Venlafaxine is more _________ at a higher dose.

Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), has dose-dependent effects, particularly noticeable at higher doses. At lower doses, it primarily acts as a selective serotonin reuptake inhibitor (SSRI), contributing to a calming effect. However, as the dosage is increased, venlafaxine also significantly enhances norepinephrine reuptake inhibition. This increased norepinephrine activity can lead to a more stimulating or activating effect on the central nervous system.

This stimulating nature at higher doses can manifest as increased energy, improved mood, or even symptoms like increased heart rate or restlessness in some individuals. Therefore, recognizing the shift in effects as the dosage of venlafaxine increases is crucial for understanding its clinical use and tailoring treatment to individual patient needs.