What are the potential effects of Dextromethorphan + Bupropion on mood?

The combination of Dextromethorphan and Bupropion can have a significant impact on mood, particularly in the context of treating severe depression. Bupropion is an atypical antidepressant that primarily acts as a norepinephrine-dopamine reuptake inhibitor, which can enhance mood and alleviate depressive symptoms. It is often used in cases of major depressive disorder, and its stimulating effects can counteract fatigue and increase energy levels in individuals dealing with severe depression.

Dextromethorphan, commonly known as a cough suppressant, has been found to have potential antidepressant properties as well, especially at higher doses. Research suggests that it may act on certain neurotransmitter systems, including the NMDA receptor, which can further contribute to improving mood and providing relief from depression.

Together, these two medications could create a synergistic effect that promotes mood elevation and helps manage severe depressive symptoms effectively. This combination may be particularly useful for individuals who have not responded adequately to traditional antidepressants. Therefore, the assertion that this combination can lead to an improvement in severe depression is well-founded, given the pharmacological profiles of both Dextromethorphan and Bupropion in this context.