What condition is Dextromethorphan + Bupropion indicated for?

Dextromethorphan combined with Bupropion is indicated for the treatment of major depressive disorder in adults. Bupropion is an established antidepressant that works primarily as a norepinephrine-dopamine reuptake inhibitor, making it effective for symptoms of depression. When used in combination with dextromethorphan, which has neuroprotective and potentially mood-stabilizing properties, the treatment may enhance the antidepressant effects and provide additional benefits for patients with major depressive disorder.

This combination takes advantage of bupropion’s established efficacy in treating depression while potentially augmenting mood improvement with dextromethorphan. The option highlights the specific role of this combination in addressing the symptoms of major depressive disorder, distinguishing it from other mental health conditions like anxiety disorders, bipolar disorder, and attention deficit hyperactivity disorder, for which this specific treatment approach may not be appropriate or indicated.