What do all SNRIs require?

The correct answer emphasizes the need for renal and hepatic dose adjustments when prescribing serotonin-norepinephrine reuptake inhibitors (SNRIs). This is crucial because SNRIs are metabolized in the liver, and their elimination can be affected by the function of both the liver and kidneys. If a patient has impaired liver function, the metabolism of the drug may be altered, potentially leading to increased levels of the medication in the body, which could result in adverse effects. Similarly, renal impairment may affect the excretion of the drug, necessitating dosage adjustments to avoid toxicity.

Thus, before beginning treatment with SNRIs, healthcare providers typically evaluate a patient's renal and hepatic function to ensure safe and effective dosing, highlighting the importance of this practice in clinical settings for the ongoing safety of patients on SNRIs.