What is a common side effect of Esketamine?

Esketamine, a nasal spray form of the anesthetic ketamine, is primarily used for treatment-resistant depression. A notable side effect of eskamine is dissociation, which refers to feelings of detachment from oneself or one's surroundings. This can manifest as altered perception, a sense of floating, or experiencing the environment in a distorted manner. Dissociative effects are documented and recognized in studies of ketamine and its derivatives, which can result from its action on the NMDA receptors and impact neurotransmitter pathways in the brain.

This dissociative experience is typically transient and tends to resolve shortly after administration, although it can be unsettling for some individuals. It is essential that patients are monitored after receiving treatment, especially since episodes of dissociation may affect their safety, including their ability to drive or perform other tasks.

While memory loss, increased metabolism, and visual impairment can occur with various medications, they are not commonly associated with eskamine. The prominent and distinctive side effect of dissociation makes option B the appropriate choice in this context.