What is the maximum daily dose of Mirtazepine for adults?

Mirtazapine is an antidepressant commonly prescribed for major depressive disorder. The maximum daily dose for adults is generally considered to be 45 mg. This dosage is supported by clinical guidelines and empirical evidence that suggest that doses higher than this may not provide additional therapeutic benefits and could lead to an increased risk of side effects without significantly enhancing efficacy.

In practice, the usual starting dose of mirtazapine is often lower, typically around 15 mg, and can be titrated upwards depending on the patient’s response and tolerance to the medication. Healthcare providers carefully monitor patients and may adjust the dosage based on clinical effectiveness and the presence of any adverse effects.

Doses beyond 45 mg, such as 60 mg, 75 mg, or higher, are generally not supported by the existing clinical data, and therefore, it is essential to adhere to established dosing guidelines for safety and effectiveness.