Which antidepressant is preferred if worried about sexual dysfunction?

Bupropion is often the preferred antidepressant when there are concerns about sexual dysfunction. This is primarily because it is not associated with the sexual side effects that frequently accompany selective serotonin reuptake inhibitors (SSRIs), such as Fluoxetine and Sertraline, or tricyclic antidepressants like Amitriptyline.

Bupropion works as a norepinephrine-dopamine reuptake inhibitor, and its unique mechanism of action is one reason it tends to have a lower incidence of causing sexual side effects. Patients often report fewer issues related to libido or erectile dysfunction when taking Bupropion compared to other antidepressants. Therefore, for individuals who are particularly concerned about maintaining sexual function while managing their depression, Bupropion stands out as a suitable option.

In summary, the absence of common sexual side effects makes Bupropion an advantageous choice in the management of depression for those worried about sexual dysfunction.