Which of the following are indications of Duloxetine?

Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI), is indicated for multiple conditions, making option C the most comprehensive choice. It is approved for major depressive disorder, generalized anxiety disorder (GAD), and also plays a significant role in chronic pain management, particularly in conditions such as diabetic peripheral neuropathy and fibromyalgia.

Duloxetine is valuable in treating both mood disorders and physical pain, which distinguishes it from other medications that may be more narrowly focused. This versatility makes it particularly useful in clinical practice when treating patients who may have overlapping symptoms of depression and chronic pain or anxiety.

While diabetic peripheral neuropathy and fibromyalgia are indeed specific indications for Duloxetine, they are part of a more extensive list of uses that also includes depression and GAD. Consequently, this broader scope of application reinforces why option C encompasses vital aspects of Duloxetine's therapeutic role, thus making it the correct choice.