Which of the following medications is NOT classified as a TCA?

Sertraline is classified as a selective serotonin reuptake inhibitor (SSRI), which is a different class of antidepressants compared to tricyclic antidepressants (TCAs). SSRIs like sertraline work primarily by increasing the level of serotonin in the brain, which can help improve mood and alleviate symptoms of depression and anxiety.

In contrast, the other options listed—maprotiline, amitriptyline, and nortriptyline—are all classified as TCAs. TCAs are older antidepressants that influence multiple neurotransmitters, including serotonin and norepinephrine, and are known for their sedative effects and use in treating depression, anxiety disorders, and certain types of pain.

Understanding the distinction between these classes of medications is essential for recognizing their different mechanisms of action and indications for use in clinical practice.