With which class of medication should Buspirone not be given?

Buspirone should not be given with monoamine oxidase inhibitors (MAOIs) due to the potential for serious interactions. MAOIs can inhibit the breakdown of neurotransmitters, leading to an increased risk of serotonin syndrome when combined with medications like Buspirone that also affect serotonin levels. This syndrome can manifest as confusion, rapid heart rate, and in severe cases, can be life-threatening.

In contrast, Buspirone can generally be used safely with antidepressants, beta-blockers, and antipsychotics, making the combination with MAOIs particularly concerning due to the risk of adverse effects. This highlights the importance of understanding medication interactions, particularly when prescribing for anxiety and mood disorders.